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The IκBα/NF-κB complex has two hot spots, one at either end of the interface
IκBα binds to and inhibits the transcriptional activity of NF-κB family members via its ankyrin repeat (AR) domain. The binding affinity of IκBα with NF-κB(p50/p65) heterodimers and NF-κB(p65/65) homodimers is in the picomolar range, and in the cell, this results in long half-lives of the complexes....
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2590914/ https://ncbi.nlm.nih.gov/pubmed/18824506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.037481.108 |
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