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Pre-folding IκBα alters control of NF-κB signaling

Transcription complex components frequently show coupled folding and binding but the functional significance of this mode of molecular recognition is unclear. IκBα binds to and inhibits the transcriptional activity of NF-κB via its ankyrin repeat (AR) domain. The β-hairpins in ARs 5–6 in IκBα are we...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Truhlar, Stephanie M. E., Mathes, Erika, Cervantes, Carla F., Ghosh, Gourisankar, Komives, Elizabeth A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2519148/
https://ncbi.nlm.nih.gov/pubmed/18511071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.02.053
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