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Pre-folding IκBα alters control of NF-κB signaling
Transcription complex components frequently show coupled folding and binding but the functional significance of this mode of molecular recognition is unclear. IκBα binds to and inhibits the transcriptional activity of NF-κB via its ankyrin repeat (AR) domain. The β-hairpins in ARs 5–6 in IκBα are we...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2519148/ https://ncbi.nlm.nih.gov/pubmed/18511071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2008.02.053 |
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