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Regions of IκBα that are critical for its inhibition of NF-κB·DNA interaction fold upon binding to NF-κB
Nuclear factor κB (NF-κB) transcription factors regulate genes responsible for critical cellular processes. IκBα, -β, and -ε bind to NF-κBs and inhibit their transcriptional activity. The NF-κB-binding domains of IκBs contain six ankyrin repeats (ARs), which adopt a β-hairpin/α-helix/loop/α-helix/lo...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1748158/ https://ncbi.nlm.nih.gov/pubmed/17148610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605794103 |
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