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Regions of IκBα that are critical for its inhibition of NF-κB·DNA interaction fold upon binding to NF-κB

Nuclear factor κB (NF-κB) transcription factors regulate genes responsible for critical cellular processes. IκBα, -β, and -ε bind to NF-κBs and inhibit their transcriptional activity. The NF-κB-binding domains of IκBs contain six ankyrin repeats (ARs), which adopt a β-hairpin/α-helix/loop/α-helix/lo...

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Bibliografske podrobnosti
Main Authors: Truhlar, Stephanie M. E., Torpey, Justin W., Komives, Elizabeth A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1748158/
https://ncbi.nlm.nih.gov/pubmed/17148610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0605794103
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