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NF-κB dictates the degradation pathway of IκBα

IκB proteins are known as the regulators of NF-κB activity. They bind tightly to NF-κB dimers, until stimulus-responsive N-terminal phosphorylation by IKK triggers their ubiquitination and proteasomal degradation. It is known that IκBα is an unstable protein whose rapid degradation is slowed upon bi...

詳細記述

保存先:
書誌詳細
主要な著者: Mathes, Erika, O'Dea, Ellen L, Hoffmann, Alexander, Ghosh, Gourisankar
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2374849/
https://ncbi.nlm.nih.gov/pubmed/18401342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.73
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