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NF-κB dictates the degradation pathway of IκBα
IκB proteins are known as the regulators of NF-κB activity. They bind tightly to NF-κB dimers, until stimulus-responsive N-terminal phosphorylation by IKK triggers their ubiquitination and proteasomal degradation. It is known that IκBα is an unstable protein whose rapid degradation is slowed upon bi...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2374849/ https://ncbi.nlm.nih.gov/pubmed/18401342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.73 |
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