Anti-human Activin Receptor-like Kinase 1 (ALK1) Antibody Attenuates Bone Morphogenetic Protein 9 (BMP9)-induced ALK1 Signaling and Interferes with Endothelial Cell Sprouting

Genetic and molecular studies suggest that activin receptor-like kinase 1 (ALK1), a transforming growth factor β (TGF-β) type I receptor, and endoglin, a TGF-β co-receptor, play an essential role in vascular development and pathological angiogenesis. Several agents that interfere with ALK1 and endog...

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Detalhes bibliográficos
Main Authors: van Meeteren, Laurens A., Thorikay, Midory, Bergqvist, Simon, Pardali, Evangelia, Gallo Stampino, Corrado, Hu-Lowe, Dana, Goumans, Marie-José, ten Dijke, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365717/
https://ncbi.nlm.nih.gov/pubmed/22493445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.338103
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