Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-thujaplicinol Bound at the RNase H Active Site

Novel inhibitors are needed to counteract the rapid emergence of drug-resistant HIV variants. HIV-1 reverse transcriptase (RT) has both DNA polymerase and RNase H (RNH) enzymatic activities, but approved drugs that inhibit RT target the polymerase. Inhibitors that act against new targets, like RNH,...

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Hauptverfasser: Himmel, Daniel M., Maegley, Karen A., Pauly, Tom A., Bauman, Joseph D., Das, Kalyan, Dharia, Chhaya, Clark, Arthur D., Ryan, Kevin, Hickey, Michael J., Love, Robert A., Hughes, Stephen H., Bergqvist, Simon, Arnold, Eddy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365588/
https://ncbi.nlm.nih.gov/pubmed/20004166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.09.016
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