Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase

The anti-AIDS drug rilpivirine undergoes conformational changes to bind HIV-1 reverse transcriptase and retain potency against drug-resistance mutations. Our discovery that water molecules play an essential role in the drug binding is reported. Femtosecond experiments and theory expose molecular lev...

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Bibliografiske detaljer
Main Authors: Kuroda, Daniel G., Bauman, Joseph D., Challa, J. Reddy, Patel, Disha, Troxler, Thomas, Das, Kalyan, Arnold, Eddy, Hochstrasser, Robin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607437/
https://ncbi.nlm.nih.gov/pubmed/23422558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.1559
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