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Structure of HIV‐1 reverse transcriptase bound to a novel 38‐mer hairpin template‐primer DNA aptamer
The development of a modified DNA aptamer that binds HIV‐1 reverse transcriptase (RT) with ultra‐high affinity has enabled the X‐ray structure determination of an HIV‐1 RT‐DNA complex to 2.3 Å resolution without the need for an antibody Fab fragment or RT‐DNA cross‐linking. The 38‐mer hairpin‐DNA ap...
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| Publicado en: | Protein Sci |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4815302/ https://ncbi.nlm.nih.gov/pubmed/26296781 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2776 |
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