Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer

The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pair GC-rich tract and the structure of the RT-aptamer...

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Pubblicato in:Curr Res Struct Biol
Autori principali: Tuske, Steve, Zheng, Jie, Olson, Erik D., Ruiz, Francesc X., Pascal, Bruce D., Hoang, Anthony, Bauman, Joseph D., Das, Kalyan, DeStefano, Jeffrey J., Musier-Forsyth, Karin, Griffin, Patrick R., Arnold, Eddy
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8052095/
https://ncbi.nlm.nih.gov/pubmed/33870216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.crstbi.2020.06.002
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