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Integrative structural biology studies of HIV-1 reverse transcriptase binding to a high-affinity DNA aptamer
The high-resolution crystal structure of HIV-1 reverse transcriptase (RT) bound to a 38-mer DNA hairpin aptamer with low pM affinity was previously described. The high-affinity binding aptamer contained 2′-O-methyl modifications and a seven base-pair GC-rich tract and the structure of the RT-aptamer...
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| Pubblicato in: | Curr Res Struct Biol |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8052095/ https://ncbi.nlm.nih.gov/pubmed/33870216 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.crstbi.2020.06.002 |
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