Two-dimensional infrared spectra reveal relaxation of the nonnucleoside inhibitor TMC278 complexed with HIV-1 reverse transcriptase

The two nitrile groups at the wings of the nonnucleoside HIV-1 reverse transcriptase (RT) inhibitor TMC278 are both identified in high-sensitivity 2D IR spectroscopy experiments of the HIV-1 RT/TMC278 complex. The vibrational spectra indicate that the two arms of the inhibitor sense quite different...

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Hlavní autoři: Fang, Chong, Bauman, Joseph D., Das, Kalyan, Remorino, Amanda, Arnold, Eddy, Hochstrasser, Robin M.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2008
Témata:
Physical Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234168/
https://ncbi.nlm.nih.gov/pubmed/18040050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0709320104
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