TMC278, a Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor (NNRTI), Active against Wild-Type and NNRTI-Resistant HIV-1

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) have proven efficacy against human immunodeficiency virus type 1 (HIV-1). However, in the setting of incomplete viral suppression, efavirenz and nevirapine select for resistant viruses. The diarylpyrimidine etravirine has demonstrated durable e...

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Detalhes bibliográficos
Main Authors: Azijn, Hilde, Tirry, Ilse, Vingerhoets, Johan, de Béthune, Marie-Pierre, Kraus, Guenter, Boven, Katia, Jochmans, Dirk, Van Craenenbroeck, Elke, Picchio, Gaston, Rimsky, Laurence T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812151/
https://ncbi.nlm.nih.gov/pubmed/19933797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00986-09
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