TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments

TMC125 is a potent new investigational nonnucleoside reverse transcriptase inhibitor (NNRTI) that is active against human immunodeficiency virus type 1 (HIV-1) with resistance to currently licensed NNRTIs. Sequential passage experiments with both wild-type virus and NNRTI-resistant virus were perfor...

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Detalhes bibliográficos
Main Authors: Vingerhoets, Johan, Azijn, Hilde, Fransen, Els, De Baere, Inky, Smeulders, Liesbet, Jochmans, Dirk, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1235844/
https://ncbi.nlm.nih.gov/pubmed/16188980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.20.12773-12782.2005
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