TMC125 Displays a High Genetic Barrier to the Development of Resistance: Evidence from In Vitro Selection Experiments

Por Vingerhoets, Johan, Azijn, Hilde, Fransen, Els, De Baere, Inky, Smeulders, Liesbet, Jochmans, Dirk, Andries, Koen, Pauwels, Rudi, de Béthune, Marie-Pierre
Publicado em 2005

In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

Por Lenz, Oliver, Verbinnen, Thierry, Lin, Tse-I, Vijgen, Leen, Cummings, Maxwell D., Lindberg, Jimmy, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Scholliers, Annick, Vermeiren, Katrien, Ivens, Tania, Raboisson, Pierre, Edlund, Michael, Storm, Susan, Vrang, Lotta, de Kock, Herman, Fanning, Gregory C., Simmen, Kenneth A.
Publicado em 2010

TMC647055, a Potent Nonnucleoside Hepatitis C Virus NS5B Polymerase Inhibitor with Cross-Genotypic Coverage

Por Devogelaere, Benoit, Berke, Jan Martin, Vijgen, Leen, Dehertogh, Pascale, Fransen, Els, Cleiren, Erna, van der Helm, Liesbet, Nyanguile, Origène, Tahri, Abdellah, Amssoms, Katie, Lenz, Oliver, Cummings, Maxwell D., Clayton, Reginald F., Vendeville, Sandrine, Raboisson, Pierre, Simmen, Kenneth A., Fanning, Gregory C., Lin, Tse-I
Publicado em 2012

Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Por Berke, Jan Martin, Vijgen, Leen, Lachau-Durand, Sophie, Powdrill, Megan H., Rawe, Svea, Sjuvarsson, Elena, Eriksson, Staffan, Götte, Matthias, Fransen, Els, Dehertogh, Pascale, Van den Eynde, Christel, Leclercq, Laurent, Jonckers, Tim H. M., Raboisson, Pierre, Nilsson, Magnus, Samuelsson, Bertil, Rosenquist, Åsa, Fanning, Gregory C., Lin, Tse-I
Publicado em 2011