In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

TMC435 is a small-molecule inhibitor of the NS3/4A serine protease of hepatitis C virus (HCV) currently in phase 2 development. The in vitro resistance profile of TMC435 was characterized by selection experiments with HCV genotype 1 replicon cells and the genotype 2a JFH-1 system. In 80% (86/109) of...

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Autori principali: Lenz, Oliver, Verbinnen, Thierry, Lin, Tse-I, Vijgen, Leen, Cummings, Maxwell D., Lindberg, Jimmy, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Scholliers, Annick, Vermeiren, Katrien, Ivens, Tania, Raboisson, Pierre, Edlund, Michael, Storm, Susan, Vrang, Lotta, de Kock, Herman, Fanning, Gregory C., Simmen, Kenneth A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863659/
https://ncbi.nlm.nih.gov/pubmed/20176898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01452-09
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