In Vitro Resistance Profile of the Hepatitis C Virus NS3/4A Protease Inhibitor TMC435

TMC435 is a small-molecule inhibitor of the NS3/4A serine protease of hepatitis C virus (HCV) currently in phase 2 development. The in vitro resistance profile of TMC435 was characterized by selection experiments with HCV genotype 1 replicon cells and the genotype 2a JFH-1 system. In 80% (86/109) of...

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Autors principals: Lenz, Oliver, Verbinnen, Thierry, Lin, Tse-I, Vijgen, Leen, Cummings, Maxwell D., Lindberg, Jimmy, Berke, Jan Martin, Dehertogh, Pascale, Fransen, Els, Scholliers, Annick, Vermeiren, Katrien, Ivens, Tania, Raboisson, Pierre, Edlund, Michael, Storm, Susan, Vrang, Lotta, de Kock, Herman, Fanning, Gregory C., Simmen, Kenneth A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2010
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863659/
https://ncbi.nlm.nih.gov/pubmed/20176898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01452-09
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