In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor

The hepatitis C virus (HCV) NS3/4A serine protease has been explored as a target for the inhibition of viral replication in preclinical models and in HCV-infected patients. TMC435350 is a highly specific and potent inhibitor of NS3/4A protease selected from a series of novel macrocyclic inhibitors....

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Autors principals: Lin, Tse-I, Lenz, Oliver, Fanning, Gregory, Verbinnen, Thierry, Delouvroy, Frédéric, Scholliers, Annick, Vermeiren, Katrien, Rosenquist, Åsa, Edlund, Michael, Samuelsson, Bertil, Vrang, Lotta, de Kock, Herman, Wigerinck, Piet, Raboisson, Pierre, Simmen, Kenneth
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663092/
https://ncbi.nlm.nih.gov/pubmed/19171797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01058-08
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