Structural and Thermodynamic Basis for the Binding of TMC114, a Next-Generation Human Immunodeficiency Virus Type 1 Protease Inhibitor

TMC114, a newly designed human immunodeficiency virus type 1 (HIV-1) protease inhibitor, is extremely potent against both wild-type (wt) and multidrug-resistant (MDR) viruses in vitro as well as in vivo. Although chemically similar to amprenavir (APV), the potency of TMC114 is substantially greater....

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Autors principals: King, Nancy M., Prabu-Jeyabalan, Moses, Nalivaika, Ellen A., Wigerinck, Piet, de Béthune, Marie-Pierre, Schiffer, Celia A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC523255/
https://ncbi.nlm.nih.gov/pubmed/15479840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.21.12012-12021.2004
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