Substrate Envelope and Drug Resistance: Crystal Structure of RO1 in Complex with Wild-Type Human Immunodeficiency Virus Type 1 Protease

In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved “envelope” that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease...

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Main Authors: Prabu-Jeyabalan, Moses, King, Nancy M., Nalivaika, Ellen A., Heilek-Snyder, Gabrielle, Cammack, Nick, Schiffer, Celia A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2006
Assuntos:
Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1426980/
https://ncbi.nlm.nih.gov/pubmed/16569872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1518-1521.2006
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