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Substrate Envelope and Drug Resistance: Crystal Structure of RO1 in Complex with Wild-Type Human Immunodeficiency Virus Type 1 Protease
In our previous crystallographic studies of human immunodeficiency virus type 1 (HIV-1) protease-substrate complexes, we described a conserved “envelope” that appears to be important for substrate recognition and the selection of drug-resistant mutations. In this study, the complex of HIV-1 protease...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1426980/ https://ncbi.nlm.nih.gov/pubmed/16569872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.4.1518-1521.2006 |
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