Mechanism of Substrate Recognition by Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variants Revealed by a Novel Structural Intermediate

Human immunodeficiency virus type 1 (HIV-1) protease processes and cleaves the Gag and Gag-Pol polyproteins, allowing viral maturation, and therefore is an important target for antiviral therapy. Ligand binding occurs when the flaps open, allowing access to the active site. This flexibility in flap...

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Detalhes bibliográficos
Main Authors: Prabu-Jeyabalan, Moses, Nalivaika, Ellen A., Romano, Keith, Schiffer, Celia A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440387/
https://ncbi.nlm.nih.gov/pubmed/16537628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.7.3607-3616.2006
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