Structural and Thermodynamic Basis of Amprenavir/Darunavir and Atazanavir Resistance in HIV-1 Protease with Mutations at Residue 50

Drug resistance occurs through a series of subtle changes that maintain substrate recognition but no longer permit inhibitor binding. In HIV-1 protease, mutations at I50 are associated with such subtle changes that confer differential resistance to specific inhibitors. Residue I50 is located at the...

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Главные авторы: Mittal, Seema, Bandaranayake, Rajinthna M., King, Nancy M., Prabu-Jeyabalan, Moses, Nalam, Madhavi N. L., Nalivaika, Ellen A., Kurt Yilmaz, Nese, Schiffer, Celia A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2013
Предметы:
Vaccines and Antiviral Agents
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624360/
https://ncbi.nlm.nih.gov/pubmed/23365446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.03486-12
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