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Extreme Entropy-Enthalpy Compensation in a Drug Resistant Variant of HIV-1 Protease
The development of HIV-1 protease inhibitors has been the historic paradigm of rational structure-based drug design, where structural and thermodynamic analyses have assisted in the discovery of novel inhibitors. While the total enthalpy and entropy change upon binding determine the affinity, often...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594831/ https://ncbi.nlm.nih.gov/pubmed/22712830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300191k |
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