Extreme Entropy-Enthalpy Compensation in a Drug Resistant Variant of HIV-1 Protease

The development of HIV-1 protease inhibitors has been the historic paradigm of rational structure-based drug design, where structural and thermodynamic analyses have assisted in the discovery of novel inhibitors. While the total enthalpy and entropy change upon binding determine the affinity, often...

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Hlavní autoři: King, Nancy M., Prabu-Jeyabalan, Moses, Bandaranayake, Rajintha M., Nalam, Madhavi N. L., Nalivaika, Ellen A., Özen, Ayşegül, Haliloglu, Türkan, Yılmaz, Neşe Kurt, Schiffer, Celia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594831/
https://ncbi.nlm.nih.gov/pubmed/22712830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300191k
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