Molecular Basis for Drug Resistance in HIV-1 Protease

HIV-1 protease is one of the major antiviral targets in the treatment of patients infected with HIV-1. The nine FDA approved HIV-1 protease inhibitors were developed with extensive use of structure-based drug design, thus the atomic details of how the inhibitors bind are well characterized. From thi...

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Detalhes bibliográficos
Main Authors: Ali, Akbar, Bandaranayake, Rajintha M., Cai, Yufeng, King, Nancy M., Kolli, Madhavi, Mittal, Seema, Murzycki, Jennifer F., Nalam, Madhavi N.L., Nalivaika, Ellen A., Özen, Ayşegül, Prabu-Jeyabalan, Moses M., Thayer, Kelly, Schiffer, Celia A.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Diversity Preservation International (MDPI) 2010
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3185577/
https://ncbi.nlm.nih.gov/pubmed/21994628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v2112509
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