The Effect of Clade-Specific Sequence Polymorphisms on HIV-1 Protease Activity and Inhibitor Resistance Pathways

The majority of HIV-1 infections around the world result from non-B clade HIV-1 strains. The CRF01_AE (AE) strain is seen principally in Southeast Asia. AE protease differs by ∼10% in amino acid sequence from clade B protease and carries several naturally occurring polymorphisms that are associated...

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Detalhes bibliográficos
Main Authors: Bandaranayake, Rajintha M., Kolli, Madhavi, King, Nancy M., Nalivaika, Ellen A., Heroux, Annie, Kakizawa, Junko, Sugiura, Wataru, Schiffer, Celia A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937823/
https://ncbi.nlm.nih.gov/pubmed/20660190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00505-10
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