Improving Viral Protease Inhibitors to Counter Drug Resistance

Por Yilmaz, Nese Kurt, Swanstrom, Ronald, Schiffer, Celia A.
Publicado no Trends Microbiol (2016)

Differential Flap Dynamics in Wild-type and a Drug Resistant Variant of HIV-1 Protease Revealed by Molecular Dynamics and NMR Relaxation

Por Cai, Yufeng, Yilmaz, Nese Kurt, Myint, Wazo, Ishima, Rieko, Schiffer, Celia A.
Publicado em 2012

Molecular and Dynamic Mechanism Underlying Drug Resistance in Genotype 3 Hepatitis C NS3/4A Protease

Por Soumana, Djadé I., Yilmaz, Nese Kurt, Ali, Akbar, Prachanronarong, Kristina L., Schiffer, Celia A.
Publicado no J Am Chem Soc (2016)

Cooperative Effects of Drug-Resistance Mutations in the Flap Region of HIV-1 Protease

Por Foulkes-Murzycki, Jennifer E., Rosi, Christina, Yilmaz, Nese Kurt, Shafer, Robert W., Schiffer, Celia A.
Publicado em 2012

Dengue Protease Substrate Recognition: Binding of the Prime Side

Por Lin, Kuan-Hung, Nalivaika, Ellen A., Prachanronarong, Kristina L., Yilmaz, Nese Kurt, Schiffer, Celia A.
Publicado no ACS Infect Dis (2016)

Structural and Thermodynamic Effects of Macrocyclization in HCV NS3/4A Inhibitor MK-5172

Por Soumana, Djadé I., Yilmaz, Nese Kurt, Prachanronarong, Kristina L., Aydin, Cihan, Ali, Akbar, Schiffer, Celia A.
Publicado no ACS Chem Biol (2016)

Extreme Entropy-Enthalpy Compensation in a Drug Resistant Variant of HIV-1 Protease

Por King, Nancy M., Prabu-Jeyabalan, Moses, Bandaranayake, Rajintha M., Nalam, Madhavi N. L., Nalivaika, Ellen A., Özen, Ayşegül, Haliloglu, Türkan, Yılmaz, Neşe Kurt, Schiffer, Celia A.
Publicado em 2012

Substrate Envelope Designed Potent HIV-1 Protease Inhibitors to Avoid Drug Resistance

Por Nalam, Madhavi N.L., Ali, Akbar, Reddy, G.S. Kiran Kumar, Cao, Hong, Anjum, Saima G., Altman, Michael D., Yilmaz, Nese Kurt, Tidor, Bruce, Rana, Tariq M., Schiffer, Celia A.
Publicado em 2013