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Cooperative Effects of Drug-Resistance Mutations in the Flap Region of HIV-1 Protease

Understanding the interdependence of multiple mutations in conferring drug resistance is crucial to the development of novel and robust inhibitors. As HIV-1 protease continues to adapt and evade inhibitors while still maintaining the ability to specifically recognize and efficiently cleave its subst...

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Detalhes bibliográficos
Main Authors: Foulkes-Murzycki, Jennifer E., Rosi, Christina, Yilmaz, Nese Kurt, Shafer, Robert W., Schiffer, Celia A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3805267/
https://ncbi.nlm.nih.gov/pubmed/23252515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3006193
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