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Cooperative Effects of Drug-Resistance Mutations in the Flap Region of HIV-1 Protease
Understanding the interdependence of multiple mutations in conferring drug resistance is crucial to the development of novel and robust inhibitors. As HIV-1 protease continues to adapt and evade inhibitors while still maintaining the ability to specifically recognize and efficiently cleave its subst...
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Main Authors: | , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3805267/ https://ncbi.nlm.nih.gov/pubmed/23252515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb3006193 |
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