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Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease
Drug resistance mutations in response to HIV-1 protease inhibitors are selected not only in the drug target but elsewhere in the viral genome, especially at the protease cleavage sites in the precursor protein Gag. To understand the molecular basis of this protease–substrate coevolution, we solved t...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234576/ https://ncbi.nlm.nih.gov/pubmed/25355911 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414063111 |
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