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Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease
[Image: see text] Under the selective pressure of therapy, HIV-1 protease mutants resistant to inhibitors evolve to confer drug resistance. Such mutations can impact both the dynamics and structures of the bound and unbound forms of the enzyme. Flap+ is a multidrug-resistant variant of HIV-1 proteas...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American
Chemical Society
2014
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4132871/ https://ncbi.nlm.nih.gov/pubmed/25136270 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct4010454 |
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