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Probing Structural Changes among Analogous Inhibitor-Bound Forms of HIV-1 Protease and a Drug-Resistant Mutant in Solution by NMR

In the era of state-of-the-art inhibitor design and high-resolution structural studies, detection of significant but small protein structural differences in the inhibitor-bound forms is critical to further developing the inhibitor. Here, we probed differences in HIV-1 protease (PR) conformation amon...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biochemistry
Main Authors: Khan, Shahid N, Persons, John D, Paulsen, Janet L., Guerrero, Michel, Schiffer, Celia A., Kurt-Yilmaz, Nese, Ishima, Rieko
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5850901/
https://ncbi.nlm.nih.gov/pubmed/29457713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b01238
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