Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against genotype 1 virus, and is hampered by a range of advers...

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Bibliographic Details
Main Authors: Berke, Jan Martin, Vijgen, Leen, Lachau-Durand, Sophie, Powdrill, Megan H., Rawe, Svea, Sjuvarsson, Elena, Eriksson, Staffan, Götte, Matthias, Fransen, Els, Dehertogh, Pascale, Van den Eynde, Christel, Leclercq, Laurent, Jonckers, Tim H. M., Raboisson, Pierre, Nilsson, Magnus, Samuelsson, Bertil, Rosenquist, Åsa, Fanning, Gregory C., Lin, Tse-I
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147651/
https://ncbi.nlm.nih.gov/pubmed/21576430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00214-11
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