Antiviral Activity and Mode of Action of TMC647078, a Novel Nucleoside Inhibitor of the Hepatitis C Virus NS5B Polymerase

Chronic infection with hepatitis C virus (HCV) is a major global health burden and is associated with an increased risk of liver cirrhosis and hepatocellular carcinoma. Current therapy for HCV infection has limited efficacy, particularly against genotype 1 virus, and is hampered by a range of advers...

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Bibliographische Detailangaben
Hauptverfasser: Berke, Jan Martin, Vijgen, Leen, Lachau-Durand, Sophie, Powdrill, Megan H., Rawe, Svea, Sjuvarsson, Elena, Eriksson, Staffan, Götte, Matthias, Fransen, Els, Dehertogh, Pascale, Van den Eynde, Christel, Leclercq, Laurent, Jonckers, Tim H. M., Raboisson, Pierre, Nilsson, Magnus, Samuelsson, Bertil, Rosenquist, Åsa, Fanning, Gregory C., Lin, Tse-I
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147651/
https://ncbi.nlm.nih.gov/pubmed/21576430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00214-11
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