TMC125, a Novel Next-Generation Nonnucleoside Reverse Transcriptase Inhibitor Active against Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Human Immunodeficiency Virus Type 1

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent inhibitors of human immunodeficiency virus type 1 (HIV-1); however, currently marketed NNRTIs rapidly select resistant virus, and cross-resistance within the class is extensive. A parallel screening strategy was applied to test candi...

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Bibliographische Detailangaben
Hauptverfasser: Andries, Koen, Azijn, Hilde, Thielemans, Theo, Ludovici, Donald, Kukla, Michael, Heeres, Jan, Janssen, Paul, De Corte, Bart, Vingerhoets, Johan, Pauwels, Rudi, de Béthune, Marie-Pierre
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC529207/
https://ncbi.nlm.nih.gov/pubmed/15561844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4680-4686.2004
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