High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations

TMC278 is a diarylpyrimidine (DAPY) nonnucleoside reverse transcriptase inhibitor (NNRTI) that is highly effective in treating wild-type and drug-resistant HIV-1 infections in clinical trials at relatively low doses (∼25–75 mg/day). We have determined the structure of wild-type HIV-1 RT complexed wi...

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Bibliographische Detailangaben
Hauptverfasser: Das, Kalyan, Bauman, Joseph D., Clark, Arthur D., Frenkel, Yulia V., Lewi, Paul J., Shatkin, Aaron J., Hughes, Stephen H., Arnold, Eddy
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234167/
https://ncbi.nlm.nih.gov/pubmed/18230722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0711209105
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