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Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening
HIV-1 reverse transcriptase (RT) undergoes a series of conformational changes during viral replication and is a central target for antiretroviral therapy. The intrinsic flexibility of RT can provide novel allosteric sites for inhibition. Crystals of RT that diffract X-rays to better than 2 Å resolut...
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| Autors principals: | , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3906421/ https://ncbi.nlm.nih.gov/pubmed/23342998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301271j |
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