Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase

We tested three compounds for their ability to inhibit the RNase H (RH) and polymerase activities of HIV-1 reverse transcriptase (RT). A high-resolution crystal structure (2.2 Å) of one of the compounds showed that it chelates the two magnesium ions at the RH active site; this prevents the RH active...

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Bibliographic Details
Published in:J Virol
Main Authors: Boyer, Paul L., Smith, Steven J., Zhao, Xue Zhi, Das, Kalyan, Gruber, Kevin, Arnold, Eddy, Burke, Terrence R., Hughes, Stephen H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2018
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6002700/
https://ncbi.nlm.nih.gov/pubmed/29643235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02203-17
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