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Developing and Evaluating Inhibitors against the RNase H Active Site of HIV-1 Reverse Transcriptase
We tested three compounds for their ability to inhibit the RNase H (RH) and polymerase activities of HIV-1 reverse transcriptase (RT). A high-resolution crystal structure (2.2 Å) of one of the compounds showed that it chelates the two magnesium ions at the RH active site; this prevents the RH active...
Guardat en:
| Publicat a: | J Virol |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6002700/ https://ncbi.nlm.nih.gov/pubmed/29643235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02203-17 |
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