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Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions

Although human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been extensively studied, there are still significant questions about the effects of mutations on the maturation and stability of RT. We show here that a significant fraction (>80%) of the single point mutations w...

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Detalhes bibliográficos
Main Authors: Dunn, Linda L., McWilliams, Mary Jane, Das, Kalyan, Arnold, Eddy, Hughes, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786724/
https://ncbi.nlm.nih.gov/pubmed/19759158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00676-09
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