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Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Make It Sensitive to Degradation by the Viral Protease in Virions Are Selected Against in Patients
Mutations in the thumb subdomain of reverse transcriptase (RT) of HIV-1 can cause this enzyme to be degraded in virions by the viral protease (PR). Many of these mutations confer a temperature-sensitive phenotype on RT and viral replication. The degradation of RT by PR appears to take place after Ga...
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| Publicado no: | Virology |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4887144/ https://ncbi.nlm.nih.gov/pubmed/26093496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2015.05.020 |
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