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Mutations in HIV-1 Reverse Transcriptase Cause Misfolding and Miscleavage by the Viral Protease
Previous work on mutations in the thumb of HIV-1 reverse transcriptase (RT) showed that the majority of the mutant RTs were degraded (by the viral protease) to various extents in virions. This degradation was, in most cases, temperature sensitive, and presumably was due to a partial unfolding of the...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3804327/ https://ncbi.nlm.nih.gov/pubmed/23850459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.06.017 |
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