HIV-1 Protease Dimer Interface Mutations that Compensate for Viral Reverse Transcriptase Instability in Infectious Virions

Mature enzymes encoded within the human immunodeficiency virus type 1 (HIV-1) genome [protease (PR), reverse transcriptase (RT) and integrase (IN)] derive from proteolytic processing of a large polyprotein (Gag-Pol). Gag-Pol processing is catalyzed by the viral PR, which is active as a homodimer. Th...

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Detalhes bibliográficos
Main Authors: Olivares, Isabel, Mulky, Alok, Boross, Peter I., Tözsér, József, Kappes, John C., López-Galíndez, Cecilio, Menéndez-Arias, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2696282/
https://ncbi.nlm.nih.gov/pubmed/17651754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.06.073
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