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Analysis of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Subunit Structure/Function in the Context of Infectious Virions and Human Target Cells

The reverse transcriptase (RT) of all retroviruses is required for synthesis of the viral DNA genome. The human immunodeficiency virus type 1 (HIV-1) RT exists as a heterodimer made up of 51-kDa and 66-kDa subunits. The crystal structure and in vitro biochemical analyses indicate that the p66 subuni...

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Detalles Bibliográficos
Main Authors: Mulky, Alok, Kappes, John C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1195396/
https://ncbi.nlm.nih.gov/pubmed/16127051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.9.3762-3769.2005
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