Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase

Two distinct mechanisms can be envisioned for resistance of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to nucleoside analogs: one in which the mutations interfere with the ability of HIV-1 RT to incorporate the analog, and the other in which the mutations enhance the exci...

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Bibliographic Details
Main Authors: Boyer, Paul L., Sarafianos, Stefan G., Arnold, Edward, Hughes, Stephen H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC114238/
https://ncbi.nlm.nih.gov/pubmed/11312355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.10.4832-4842.2001
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