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Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA
AZT (3′-azido-3′-deoxythymidine) resistance involves the enhanced excision of AZTMP from the end of the primer strand by HIV-1 reverse transcriptase. This reaction can occur when an AZTMP-terminated primer is bound at the nucleotide-binding site (pre-translocation complex N) but not at the ‘priming’...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC136941/ https://ncbi.nlm.nih.gov/pubmed/12456667 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf637 |
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