A Mutation in the 3′ Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase (Y318F) Associated with Nonnucleoside Reverse Transcriptase Inhibitor Resistance

The Y318F substitution in the 3′ region of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) has been linked to nonnucleoside RT inhibitor (NNRTI) resistance in vitro. A systematic search of a large phenotypic-genotypic database (Virco) linked the Y318F substitution with a >1...

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Detalhes bibliográficos
Main Authors: Harrigan, P. Richard, Salim, Mahboob, Stammers, David K., Wynhoven, Brian, Brumme, Zabrina L., McKenna, Paula, Larder, Brendan, Kemp, S. D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136283/
https://ncbi.nlm.nih.gov/pubmed/12050397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.13.6836-6840.2002
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