Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA

AZT (3′-azido-3′-deoxythymidine) resistance involves the enhanced excision of AZTMP from the end of the primer strand by HIV-1 reverse transcriptase. This reaction can occur when an AZTMP-terminated primer is bound at the nucleotide-binding site (pre-translocation complex N) but not at the ‘priming’...

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Main Authors: Sarafianos, Stefan G., Clark, Arthur D., Das, Kalyan, Tuske, Steve, Birktoft, Jens J., Ilankumaran, Palanichamy, Ramesha, Andagar R., Sayer, Jane M., Jerina, Donald M., Boyer, Paul L., Hughes, Stephen H., Arnold, Eddy
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2002
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC136941/
https://ncbi.nlm.nih.gov/pubmed/12456667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf637
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