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Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA

AZT (3′-azido-3′-deoxythymidine) resistance involves the enhanced excision of AZTMP from the end of the primer strand by HIV-1 reverse transcriptase. This reaction can occur when an AZTMP-terminated primer is bound at the nucleotide-binding site (pre-translocation complex N) but not at the ‘priming’...

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Udgivet i:EMBO J
Principais autores: Sarafianos, Stefan G., Clark, Arthur D., Das, Kalyan, Tuske, Steve, Birktoft, Jens J., Ilankumaran, Palanichamy, Ramesha, Andagar R., Sayer, Jane M., Jerina, Donald M., Boyer, Paul L., Hughes, Stephen H., Arnold, Eddy
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2002
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC136941/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12456667/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf637
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