HIV-1 Reverse Transcriptase Structure with RNase H Inhibitor Dihydroxy Benzoyl Naphthyl Hydrazone Bound at a Novel Site

The rapid emergence of drug-resistant variants of human immunodeficiency virus, type 1 (HIV-1), has limited the efficacy of anti-acquired immune deficiency syndrome (AIDS) treatments, and new lead compounds that target novel binding sites are needed. We have determined the 3.15 Å resolution crystal...

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Detalhes bibliográficos
Main Authors: Himmel, Daniel M., Sarafianos, Stefan G., Dharmasena, Sanjeewa, Hossain, Mohammed M., McCoy-Simandle, Kessler, Ilina, Tatiana, Clark, Arthur D., Knight, Jennifer L., Julias, John G., Clark, Patrick K., Krogh-Jespersen, Karsten, Levy, Ronald M., Hughes, Stephen H., Parniak, Michael A., Arnold, Eddy
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963427/
https://ncbi.nlm.nih.gov/pubmed/17184135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb600303y
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