Effect of tRNA on the maturation of HIV-reverse transcriptase

The mature HIV-1 reverse transcriptase is a heterodimer that comprises 66 kDa (p66) and 51 kDa (p51) subunits. The latter is formed by HIV-1 protease-catalyzed removal of a C-terminal ribonuclease H domain from a p66 subunit. This proteolytic processing is a critical step in virus maturation and ess...

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Bibliographic Details
Published in:J Mol Biol
Main Authors: Ilina, Tatiana V., Slack, Ryan L., Elder, John H., Sarafianos, Stefan G., Parniak, Michael A., Ishima, Rieko
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988984/
https://ncbi.nlm.nih.gov/pubmed/29751015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.02.027
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