Reviving B-Factors: Activating ALK Mutations Increase Protein Dynamics of the Unphosphorylated Kinase

[Image: see text] Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that can become oncogenic by activating mutations or overexpression. Full kinetic characterization of both phosphorylated and nonphosphorylated wildtype and mutant ALK kinase domain was done. Our structure-based drug de...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Principais autores: Johnson, Ted W., Bolanos, Ben, Brooun, Alexei, Gallego, Rebecca A., Gehlhaar, Dan, Jalaie, Mehran, McTigue, Michele, Timofeevski, Sergei
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6142052/
https://ncbi.nlm.nih.gov/pubmed/30258533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00348
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