The Axl kinase domain in complex with a macrocyclic inhibitor offers first structural insights into an active TAM receptor kinase

The receptor tyrosine kinase family consisting of Tyro3, Axl, and Mer (TAM) is one of the most recently identified receptor tyrosine kinase families. TAM receptors are up-regulated postnatally and maintained at high levels in adults. They all play an important role in immunity, but Axl has also been...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Gajiwala, Ketan S., Grodsky, Neil, Bolaños, Ben, Feng, Junli, Ferre, RoseAnn, Timofeevski, Sergei, Xu, Meirong, Murray, Brion W., Johnson, Ted W., Stewart, Al
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612104/
https://ncbi.nlm.nih.gov/pubmed/28724631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.771485
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